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KMID : 0605620160230010012
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Journal of Korean Society of Biological Psychiatry
2016 Volume.23 No. 1 p.12 ~ p.17
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Neuroinflammation and Psychiatric Illness
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송후림:Song Hoo-Rim
이화영:Lee Hwa-Young/심세훈:Shim Se-Hoon/권영준:Kwon Young-Joon
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Abstract
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Neuroinflammation is one of important allostatic loads contributory to the various psychiatric illness. It is mediated mainly by glial cells, which produce both proinflammatory and antiinflammatory cytokines, and the balance of them determines the inflammatory process in the central nervous system. S100 calcium-binding protein B, which is used as an inflammatory marker is also released by glial cells. In the molecular level, oxidative stress contributes to the neuroinflammation. Their disturbances have been revealed in the psychiatric illness and related with the dysregulation of the glutamatergic and monoaminergic systems. There is a possibility to use them as disease markers. The approach for inflammation using antiinflammatory drugs and antioxidants could be connected to the development of disease-modifying treatments. Also, a searching examination about specific subtypes who are vulnerable to inflammation in the patients is required to confirm their efficacy clearly.
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KEYWORD
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Neuroinflammation, Cytokine, S100B, Oxidative stress
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